Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 19/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 19/20 | 0.55 |
| ▸ | MAPT | P10636 | 16/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.55 |
| ▸ | RECQL | P46063 | 10/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | POLB | P06746 | 9/20 | 0.49 |
| ▸ | BLM | P54132 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.48 |
| ▸ | THRB | P10828 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | CASP6 | P55212 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | G6PD | P11413 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135755 | 0.83 | KMT2A (0.53) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7134821 | 0.83 | KMT2A (0.43) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7132947 | 0.82 | ERBB2 (0.57) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7130491 | 0.81 | KMT2A (0.48) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7137068 | 0.80 | MAPT (0.32) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7135668 | 0.80 | XDH (0.57) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7138194 | 0.80 | EGFR (0.51) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL7138227 | 0.78 | METAP1 (0.54) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7135552 | 0.76 | ERBB2 (0.34) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL7138197 | 0.76 | KMT2A (0.54) | MEN1KMT2AMAPTKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |