Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139579 | 0.80 | RET (0.38) | CYP11B2RETTDP1NTRK1RAF1 | |
| SCHEMBL5365774 | 0.79 | IKBKB (0.41) | RAF1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6291705 | 0.78 | PARP1 (0.47) | CYP11B2CHEK1RETTDP1NTRK1 | |
| SCHEMBL6291703 | 0.78 | PARP1 (0.47) | CYP11B2CHEK1RETTDP1NTRK1 | |
| SCHEMBL5728224 | 0.77 | CHEK1 (0.60) | CHEK1RETTDP1NTRK1MEN1 | |
| SCHEMBL5728227 | 0.77 | CHEK1 (0.60) | CHEK1RETTDP1NTRK1MEN1 | |
| SCHEMBL15503691 | 0.77 | CHEK1 (0.60) | CHEK1RETTDP1NTRK1MEN1 | |
| SCHEMBL5363068 | 0.76 | GSK3B (0.51) | RAF1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL22409625 | 0.76 | KMT2A (0.51) | CYP11B2TDP1MEN1ALDH1A1MAPT | |
| SCHEMBL8529758 | 0.76 | PDPK1 (0.52) | CHEK1RETTDP1NTRK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |