Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134339 | 0.83 | RET (0.45) | RETFLT3ACVR1RAF1BMPR1B | |
| SCHEMBL7130494 | 0.80 | CYP11B2 (0.38) | RETFLT3ACVR1RAF1CYP11B2 | |
| SCHEMBL7138169 | 0.80 | POLB (0.42) | RETFLT3RAF1ALDH1A1CYP1A2 | |
| SCHEMBL7136829 | 0.79 | GSK3B (0.50) | RAF1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7139425 | 0.79 | KMT2A (0.49) | RETFLT3ALDH1A1CYP1A2MEN1 | |
| SCHEMBL7138232 | 0.78 | NTRK1 (0.52) | RETFLT3ALDH1A1HPGDMEN1 | |
| SCHEMBL7137055 | 0.77 | GSK3B (0.49) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL7138946 | 0.77 | NPC1 (0.48) | FLT3RAF1ALDH1A1HPGDMEN1 | |
| SCHEMBL7134752 | 0.77 | PLK4 (0.48) | RAF1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7134889 | 0.77 | DYRK1A (0.39) | ALDH1A1MEN1MAPTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |