Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | AXL | P30530 | 1/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | SCN4A | P35499 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13780339 | 0.90 | RAB9A (0.81) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL1601650 | 0.86 | RAB9A (0.75) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL27586243 | 0.84 | RAB9A (1.00) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL21179449 | 0.82 | AXL (0.60) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL78948 | 0.81 | GFER (1.00) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL1913552 | 0.80 | RAB9A (0.70) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL2918453 | 0.79 | ALDH1A1 (0.72) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL3113690 | 0.78 | RAB9A (0.72) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL785395 | 0.77 | RAB9A (0.70) | RAB9AAXLGFERNPC1SMN1; SMN2 | |
| SCHEMBL142514 | 0.77 | RAB9A (1.00) | RAB9AAXLGFERNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1440383-A | PPAR gamma modulators | SANKYO CO (JP) | 2003-09-03 | — | — | CN | disclosed |
| US-20030134859-A1 | PPAR-gamma modulator | SANKYO COMPANY, LIMITED (JP) | 2003-07-17 | — | — | US | disclosed |
| EP-1277729-A1 | PPAR (GAMMA) MODULATORS | Sankyo Company, Limited (JP) | 2003-01-22 | — | — | EP | disclosed |
| CN-1021047-C | 1,5-BENZOTHIAZEPINE DERIVATIVE AND PREPARATION THEREOF | SANKYO CO (JP) | 1993-06-02 | — | — | CN | disclosed |
| EP-0353032-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | Sankyo Company Limited (JP) | 1992-02-26 | — | — | EP | disclosed |
| US-5002942-A | Calcium channel blockers for cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1991-03-26 | — | — | US | disclosed |
| CN-1040195-A | 1,5-benzo thiophene azepine derivative and its preparation method and their application in the treatment cardiovascular disorder | SANKYO CO (JP) | 1990-03-07 | — | — | CN | disclosed |
| EP-0353032-A1 | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134859-A1 | PPAR-gamma modulator | PPARG, PPARA, PPARD | RAB9A 1179/4885AXL 2513/4885GFER 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.