Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.50 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067150 | 1.00 | CA1 (0.52) | CA1CA2CA4CA7LRRK2 | |
| SCHEMBL1491241 | 0.75 | LRRK2 (0.53) | CA1CA2CA4CA7LRRK2 | |
| SCHEMBL1491242 | 0.75 | LRRK2 (0.53) | CA1CA2CA4CA7LRRK2 | |
| SCHEMBL7740292 | 0.73 | LRRK2 (0.62) | LRRK2IDO1KMT2AMEN1GAA | |
| SCHEMBL14405656 | 0.73 | LRRK2 (0.62) | LRRK2IDO1KMT2AMEN1GAA | |
| SCHEMBL12804786 | 0.73 | LRRK2 (0.67) | LRRK2IDO1KMT2AMEN1GAA | |
| SCHEMBL12971379 | 0.73 | LRRK2 (0.67) | LRRK2IDO1KMT2AMEN1GAA | |
| SCHEMBL12804785 | 0.73 | LRRK2 (0.67) | LRRK2IDO1KMT2AMEN1GAA | |
| SCHEMBL28915857 | 0.72 | LRRK2 (0.53) | CA1CA2CA4CA7LRRK2 | |
| SCHEMBL7745690 | 0.72 | LRRK2 (0.53) | LRRK2IDO1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-29 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| EP-0818193-B1 | Quaternized blue anthraquinone hair dyes in an isatin/amine dye system | CLAIROL INC (US) | 2003-05-28 | — | — | EP | disclosed |
| US-5746779-A | Quaternized blue anthraqinone hair dyes in an isatin/amine dye system | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0818193-A2 | Quaternized blue anthraquinone hair dyes in an isatin/amine dye system | Bristol-Myers Squibb Company (US) | 1998-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | JAK2, ERBB2, CDC25C | CA1 2208/4885CA2 2006/4885CA4 3783/4885 |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | CA1 4667/4885CA2 3307/4885CA4 4083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.