Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365162 | 0.83 | GSK3B (0.48) | PDPK1LRRK2MAOAMAOBGSK3B | |
| SCHEMBL13080589 | 0.83 | LRRK2 (0.61) | PDGFRBLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7137938 | 0.82 | LRRK2 (0.46) | PDPK1LRRK2MAOAMAOBGSK3B | |
| SCHEMBL13080586 | 0.81 | FLT3 (0.56) | PDGFRBEGFRCSF1RKITPIM1 | |
| SCHEMBL1388393 | 0.81 | PDPK1 (0.54) | PDGFRBEGFRCSF1RKITPDPK1 | |
| SCHEMBL1388519 | 0.81 | RET (0.54) | PDGFRBEGFRCSF1RKITPDPK1 | |
| SCHEMBL7138968 | 0.81 | MAPT (0.49) | PDGFRBEGFRCSF1RKITPIM1 | |
| SCHEMBL7874137 | 0.80 | GSK3B (0.59) | PDGFRBEGFRCSF1RKITPIM1 | |
| SCHEMBL8291555 | 0.80 | GSK3B (0.59) | PDGFRBEGFRCSF1RKITPIM1 | |
| SCHEMBL5361803 | 0.79 | LRRK2 (0.65) | PDGFRBPDPK1PIM1LRRK2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |