Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 5/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30307401 | 0.84 | HRH3 (0.53) | HRH3GBA1PIK3CDLMNAPIK3R1 | |
| SCHEMBL15453232 | 0.72 | HRH3 (0.56) | HRH3KDM4E | |
| SCHEMBL31457947 | 0.71 | PTGS1 (0.51) | MAOBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL12772106 | 0.70 | MEN1 (0.55) | TAAR1MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL16596266 | 0.70 | HRH3 (0.64) | HRH3GBA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL827779 | 0.69 | HRH3 (0.51) | HRH3KDM4E | |
| SCHEMBL15453256 | 0.69 | HRH3 (0.56) | HRH3MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9652160 | 0.68 | HRH3 (0.62) | HRH3LMNASMN1; SMN2 | |
| SCHEMBL171949 | 0.68 | TAAR1 (0.66) | TAAR1MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL30798825 | 0.68 | TAAR1 (0.66) | TAAR1MEN1KMT2AOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002036586-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2002-05-10 | — | — | WO | disclosed |