SCHEMBL7133156

SCHEMBL7133156

NC(CCC[C@](N)(C(=O)O)C(=O)OCc1ccccc1)C(=O)OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.43
SLC1A1 P43005 4/20 0.43
SLC1A3 P43003 3/20 0.43
SLC15A1 P46059 1/20 0.41
IDO1 P14902 1/20 0.41
SLC1A2 P43004 2/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
DPP8 Q6V1X1 2/20 0.40
DPP7 Q9UHL4 2/20 0.40
DPP4 P27487 1/20 0.40
DPP9 Q86TI2 1/20 0.40
ALDH1A1 P00352 3/20 0.40
ALPI P09923 1/20 0.40
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10421087 0.93 SLC1A1 (0.46) SMN1; SMN2HIF1ASLC1A1SLC1A3SLC15A1
SCHEMBL10420617 0.91 LTA4H (0.43) SMN1; SMN2HIF1ASLC1A1SLC1A3SLC15A1
SCHEMBL7258076 0.90 TSHR (0.48) SMN1; SMN2HIF1ASLC1A1SLC1A3ALDH1A1
SCHEMBL10700924 0.89 LTA4H (0.45) SMN1; SMN2HIF1ASLC1A1SLC1A3IDO1
SCHEMBL11011081 0.89 LTA4H (0.50) SMN1; SMN2HIF1ASLC1A1SLC1A3SLC15A1
SCHEMBL10421090 0.87 SMN1; SMN2 (0.46) SMN1; SMN2HIF1ASLC1A1SLC1A3SLC15A1
SCHEMBL10491547 0.85 SMN1; SMN2 (0.44) SMN1; SMN2HIF1ASLC1A1SLC1A3SLC1A2
SCHEMBL11190878 0.84 POLB (0.46) SLC15A1KMT2AMEN1ALPIPKM
SCHEMBL10855143 0.83 SMN1; SMN2 (0.47) SMN1; SMN2HIF1AKMT2AALDH1A1LTA4H
SCHEMBL10855149 0.83 SMN1; SMN2 (0.47) SMN1; SMN2HIF1AKMT2AALDH1A1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6585786-B2 Slurry for chemical mechanical polishing NEC ELECTRONICS CORPORATION (JP) 2003-07-01 US disclosed
US-20020095874-A1 Slurry for chemical mechanical polishing NEC CORPORATION 2002-07-25 US disclosed
EP-0839814-A2 Indolocarbazole derivatives and their use for the treatment of prostate gland disorders CEPHALON, INC. (US) 1998-05-06 EP disclosed
EP-0699204-B1 USE OF INDOLOCARBAZOLE DERIVATIVES TO TREAT A PATHOLOGICAL CONDITION OF THE PROSTATE CEPHALON INC (US) 1998-04-15 EP disclosed
US-5654427-A PROTEIN KINASE INHIBITORS KYOWA HAKKO KOGYO CO., LTD. (JP) 1997-08-05 US disclosed
US-5516771-A Use of indolocarbazole derivatives to treat a pathological condition of the prostate CEPHALON, INC. (US) 1996-05-14 US disclosed
US-4376766-A Anti-sickling agents G.D. SEARLE & CO. (US) 1983-03-15 US disclosed