Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377025 | 0.89 | RET (0.54) | RETHPGDLRRK2PDGFRBIGF1R | |
| SCHEMBL7136100 | 0.86 | RET (0.67) | RETHPGDLRRK2PDGFRBIGF1R | |
| SCHEMBL7140011 | 0.85 | PPARG (0.61) | RETHPGDMMP3MMP13MAOA | |
| SCHEMBL7130522 | 0.85 | ADAMTS5 (0.51) | RETAKR1B1MMP3MMP13MAOA | |
| SCHEMBL7133306 | 0.85 | ADAMTS5 (0.50) | RETAKR1B1HPGDLRRK2NTRK1 | |
| SCHEMBL7134014 | 0.83 | RET (0.48) | RETHPGDLRRK2PDGFRBIGF1R | |
| SCHEMBL7137035 | 0.83 | PIM1 (0.48) | RETHPGDLRRK2PDGFRBPSEN1 | |
| SCHEMBL5370263 | 0.83 | ERBB2 (0.44) | RETLRRK2PDGFRBIGF1RNTRK1 | |
| SCHEMBL7133303 | 0.82 | AKR1B1 (0.45) | RETAKR1B1HPGDMMP3MMP13 | |
| SCHEMBL7136320 | 0.82 | ADAMTS5 (0.54) | RETAKR1B1MMP3MMP13LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |