Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CTRC | Q99895 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377025 | 0.92 | RET (0.54) | RETLRRK2RAF1PDGFRBIGF1R | |
| SCHEMBL7134014 | 0.87 | RET (0.48) | RETLRRK2RAF1PDGFRBIGF1R | |
| SCHEMBL7136206 | 0.86 | RET (0.50) | RETLRRK2PDGFRBIGF1RERBB2 | |
| SCHEMBL7134022 | 0.84 | LRRK2 (0.48) | RETLRRK2ERBB2 | |
| SCHEMBL7137405 | 0.82 | IGF1R (0.45) | RETSIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL7132867 | 0.82 | PDGFRB (0.55) | RETSIRT2SIRT1SIRT5LRRK2 | |
| SCHEMBL5367625 | 0.82 | METAP1 (0.56) | RETPDGFRBMEN1KMT2AALDH1A1 | |
| SCHEMBL7134871 | 0.82 | RET (0.44) | RETLRRK2RAF1PDGFRBIGF1R | |
| SCHEMBL5358699 | 0.82 | GSK3B (0.45) | RETLRRK2RAF1PDGFRBIGF1R | |
| SCHEMBL7140011 | 0.82 | PPARG (0.61) | RETSIRT2SIRT1SIRT3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |