Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139579 | 0.83 | RET (0.38) | RETFLT3GSK3BTDP1ACVR1 | |
| SCHEMBL7132935 | 0.78 | MEN1 (0.56) | RETFLT3GSK3BMEN1KMT2A | |
| SCHEMBL7131400 | 0.76 | MEN1 (0.42) | RETFLT3GSK3BMEN1KMT2A | |
| SCHEMBL7131343 | 0.76 | NPC1 (0.56) | RETFLT3GSK3BMEN1KMT2A | |
| SCHEMBL5369681 | 0.76 | GSK3B (0.49) | RETFLT3GSK3BMEN1KMT2A | |
| SCHEMBL5728227 | 0.76 | CHEK1 (0.60) | RETFLT3GSK3BTDP1MEN1 | |
| SCHEMBL5728224 | 0.76 | CHEK1 (0.60) | RETFLT3GSK3BTDP1MEN1 | |
| SCHEMBL15503691 | 0.76 | CHEK1 (0.60) | RETFLT3GSK3BTDP1MEN1 | |
| SCHEMBL5377025 | 0.76 | RET (0.54) | RETTDP1MEN1KMT2AMAPT | |
| SCHEMBL7130446 | 0.76 | NTRK1 (0.63) | RETGSK3BTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |