Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134657 | 1.00 | TACR1 (0.44) | TACR1SLC6A4SLC6A3SLC6A2RAB9A | |
| SCHEMBL6984627 | 0.82 | TACR1 (0.47) | TACR1SLC6A4SLC6A3SLC6A2RAB9A | |
| SCHEMBL6984751 | 0.82 | TACR1 (0.47) | TACR1SLC6A4SLC6A3SLC6A2RAB9A | |
| SCHEMBL7555122 | 0.75 | TACR1 (0.59) | TACR1SLC6A4SLC6A3SLC6A2TACR2 | |
| SCHEMBL7555128 | 0.75 | TACR1 (0.59) | TACR1SLC6A4SLC6A3SLC6A2TACR2 | |
| SCHEMBL28272377 | 0.73 | HSD11B1 (0.40) | TACR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7139722 | 0.70 | TACR2 (0.52) | TACR1TACR2 | |
| SCHEMBL7139720 | 0.70 | TACR2 (0.52) | TACR1TACR2 | |
| SCHEMBL6984664 | 0.66 | TACR1 (0.61) | TACR1TACR2 | |
| SCHEMBL8150748 | 0.65 | TACR2 (0.46) | TACR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0962457-B1 | Piperidones as tachykinin antagonists | PFIZER LTD (GB) | 2003-08-06 | — | — | EP | disclosed |
| EP-0962457-A1 | Piperidones as tachykinin antagonists | Pfizer Limited (GB) | 1999-12-08 | — | — | EP | disclosed |