Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138812 | 0.83 | KCNH2 (0.76) | LTA4HKCNH2MCHR1MAOBHTT | |
| SCHEMBL11244902 | 0.83 | LTA4H (0.81) | LTA4HHTTHRH3KDM4EALDH1A1 | |
| SCHEMBL14970473 | 0.83 | LTA4H (0.81) | LTA4HHTTHRH3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL14969107 | 0.82 | LTA4H (0.79) | LTA4HHTTHRH3KDM4EALDH1A1 | |
| SCHEMBL7138782 | 0.81 | LTA4H (0.79) | LTA4HKCNH2MCHR1MAOBHTT | |
| SCHEMBL1332739 | 0.80 | KDM4E (0.67) | LTA4HKCNH2HTTHRH3KDM4E | |
| SCHEMBL14970712 | 0.80 | LTA4H (0.88) | LTA4HKCNH2MCHR1HRH3KDM4E | |
| SCHEMBL2476820 | 0.80 | LTA4H (1.00) | LTA4HKCNH2MCHR1HTTHRH3 | |
| SCHEMBL2887228 | 0.79 | MCHR1 (0.84) | LTA4HKCNH2MCHR1HRH3 | |
| Hydrochloric Acid SCHEMBL1333259 | 0.79 | KDM4E (0.65) | LTA4HKCNH2HTTHRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506876-B1 | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. | 2003-01-14 | — | — | US | disclosed |
| EP-0804427-B1 | LTA4 HYDROLASE INHIBITORS | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1221441-A2 | LTA4 Hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5585492-A | USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES WHICH ARE MEDIATED BY LTB4 PRODUCTION, SUCH AS PSORIASIS, ULCERATIVE COLITIS, IRRITABLE BOWEL DISEASE AND ASTHMA | G. D. SEARLE & CO. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |