Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136583 | 0.90 | ALDH1A1 (0.38) | PTPN1ALDH1A1POLBPTPN2MAPT | |
| SCHEMBL7130441 | 0.85 | KMT2A (0.49) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL7138379 | 0.85 | RET (0.48) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL5367226 | 0.82 | PTPN1 (0.44) | PTPN1ALDH1A1POLBPTPN2MAPT | |
| SCHEMBL7138197 | 0.80 | KMT2A (0.54) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL7131028 | 0.78 | ALDH1A1 (0.33) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL7138851 | 0.77 | IGF1R (0.44) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL7134033 | 0.77 | MAPT (0.51) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL7138194 | 0.77 | EGFR (0.51) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL7131043 | 0.76 | PIM1 (0.45) | ALDH1A1POLBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |