Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.49 |
| ▸ | MEN1 | O00255 | 13/20 | 0.49 |
| ▸ | POLB | P06746 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138379 | 0.90 | RET (0.48) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7135682 | 0.85 | PTPN1 (0.38) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7136583 | 0.84 | ALDH1A1 (0.38) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7138197 | 0.83 | KMT2A (0.54) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7131028 | 0.82 | ALDH1A1 (0.33) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7134033 | 0.81 | MAPT (0.51) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL5364403 | 0.81 | KMT2A (0.56) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7131043 | 0.80 | PIM1 (0.45) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7138862 | 0.77 | MAPT (0.47) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL7138182 | 0.77 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |