Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | LIG1 | P18858 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174686 | 0.89 | CYP3A4 (0.74) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL7314986 | 0.88 | ADRB2 (0.60) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL27540719 | 0.86 | CYP3A4 (0.60) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL7756816 | 0.84 | CYP3A4 (0.72) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL11799975 | 0.84 | CYP3A4 (0.83) | CYP3A4ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL536025 | 0.84 | TSHR (0.71) | CYP3A4ALDH1A1TSHRHSD17B10HCRTR1 | |
| SCHEMBL2407251 | 0.84 | CYP3A4 (0.66) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL10538212 | 0.83 | CYP3A4 (0.74) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| Ethane SCHEMBL28085459 | 0.82 | CYP3A4 (0.92) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 | |
| SCHEMBL12904274 | 0.82 | CYP3A4 (0.68) | CYP3A4ALDH1A1TSHRHSD17B10ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916675-B1 | Process for preparing sildenafil | PFIZER LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6066735-A | TREATMENT OF ERECTILE DYSFUNCTION | PFIZER INC. (US) | 2000-05-23 | — | — | US | disclosed |
| US-5955611-A | CYCLIZATION OF DIAMIDEPYRAZOLE TO FORM PYRIMIDONE OF PYRAZOLE | PFIZER INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0812845-B1 | Process for preparing sildenafil | PFIZER LTD (GB) | 1999-07-14 | — | — | EP | disclosed |
| EP-0916675-A2 | Process for preparing sildenafil | Pfizer Limited (GB) | 1999-05-19 | — | — | EP | disclosed |
| EP-0812845-A1 | Process for preparing sildenafil | Pfizer Limited (GB) | 1997-12-17 | — | — | EP | disclosed |