Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 5/20 | 0.54 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | MGAT1 | P26572 | 2/20 | 0.44 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136121 | 0.97 | MGAT2 (0.54) | MGAT2MOGAT2PSEN1PSEN2APH1B | |
| SCHEMBL7136606 | 0.93 | MGAT2 (0.55) | MGAT2MOGAT2PSEN1PSEN2APH1B | |
| SCHEMBL7137560 | 0.92 | CACNA1B (0.61) | MGAT2MOGAT2PSEN1PSEN2APH1B | |
| SCHEMBL5369913 | 0.89 | MOGAT2 (0.56) | MGAT2MOGAT2MGAT1 | |
| SCHEMBL5358368 | 0.88 | MOGAT2 (0.61) | MGAT2MOGAT2LRRK2 | |
| SCHEMBL7139382 | 0.87 | AR (0.64) | MGAT2MOGAT2PSEN1PSEN2APH1B | |
| SCHEMBL5369336 | 0.87 | MGAT2 (0.52) | MGAT2MOGAT2LRRK2PRKDC | |
| SCHEMBL5361465 | 0.86 | MOGAT2 (0.59) | MGAT2MOGAT2LRRK2PRKDC | |
| SCHEMBL7133915 | 0.85 | PGR (0.54) | MGAT2MOGAT2LRRK2ARPRKDC | |
| SCHEMBL5370221 | 0.85 | MOGAT2 (0.57) | MGAT2MOGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |