Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136772 | 1.00 | NFE2L2 (0.44) | NFE2L2ARHTR2AHTR2CPOLB | |
| SCHEMBL7135431 | 0.91 | NFE2L2 (0.44) | NFE2L2ARHTR2AHTR2CRELA | |
| SCHEMBL7135430 | 0.91 | NFE2L2 (0.44) | NFE2L2ARHTR2AHTR2CRELA | |
| SCHEMBL7140087 | 0.88 | AR (0.39) | ARMAPTRAB9ARELA | |
| SCHEMBL7140095 | 0.88 | AR (0.39) | ARMAPTRAB9ARELA | |
| SCHEMBL7142993 | 0.86 | KDM4E (0.38) | MAPTKCNH2 | |
| SCHEMBL7142991 | 0.86 | KDM4E (0.38) | MAPTKCNH2 | |
| SCHEMBL7135427 | 0.86 | MAOB (0.43) | NFE2L2ARMAPT | |
| SCHEMBL7133655 | 0.86 | MAOB (0.43) | NFE2L2ARMAPT | |
| SCHEMBL10358886 | 0.81 | SNCA (0.45) | NFE2L2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996439-B1 | BETA-ALKOXYACRYLATES AGAINST MALARIA | HOFFMANN LA ROCHE (CH) | 2003-01-08 | — | — | EP | claimed |
| EP-0996439-B1 | BETA-ALKOXYACRYLATES AGAINST MALARIA | HOFFMANN LA ROCHE (CH) | 2003-01-08 | — | — | EP | disclosed |
| US-6084120-A | ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID | HOFFMANN-LA ROCHE INC. (US) | 2000-07-04 | — | — | US | disclosed |