Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140624 | 0.89 | PARP1 (0.48) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL7131933 | 0.89 | PARP1 (0.54) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL7136552 | 0.86 | PARP1 (0.52) | PARP1PIM1PIM3AURKB | |
| SCHEMBL7141044 | 0.85 | PARP1 (0.48) | PARP1PIM1PIM3AURKB | |
| SCHEMBL7137094 | 0.83 | PARP1 (0.80) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL3577822 | 0.82 | MAP4K4 (0.72) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL7139317 | 0.81 | PARP1 (0.58) | PARP1PIM1PIM3AURKBBRSK1 | |
| SCHEMBL6379938 | 0.80 | PKN2 (0.41) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL7132446 | 0.80 | PARP1 (0.59) | PARP1PIM1PIM3AURKBBRSK1 | |
| SCHEMBL29696369 | 0.79 | NPC1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509365-B1 | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |