Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137161 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BCA1CA2GRIN2B | |
| SCHEMBL7137160 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BCA1CA2GRIN2B | |
| Hydrochloric Acid SCHEMBL7145984 | 0.99 | MTNR1A (0.50) | MTNR1AMTNR1BCA1CA2GRIN2B | |
| Hydrochloric Acid SCHEMBL6052543 | 0.88 | MAPT (0.44) | MTNR1AMTNR1BCA1CA2PRMT5 | |
| Hydrochloric Acid SCHEMBL7144136 | 0.88 | MAPT (0.44) | MTNR1AMTNR1BCA1CA2PRMT5 | |
| SCHEMBL7140911 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1BCA1CA2GRIN2B | |
| Hydrochloric Acid SCHEMBL27504650 | 0.77 | CA1 (0.47) | CA1CA2MAOAMAOB | |
| SCHEMBL7145514 | 0.76 | MAPT (0.46) | MTNR1AMTNR1BGRIN2BPRMT5MAPT | |
| SCHEMBL7145525 | 0.76 | MAPT (0.46) | MTNR1AMTNR1BGRIN2BPRMT5MAPT | |
| SCHEMBL2822394 | 0.76 | MTNR1A (0.56) | MTNR1AMTNR1BGRIN2BMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951465-B1 | ALPHA-AMINO ACID AMIDES, PREPARATION THEREOF AND THE THERAPEUTICAL USE THEREOF | CHIESI FARMA SPA (IT) | 2003-04-16 | — | — | EP | disclosed |
| US-6114391-A | A DERIVATIVES OF SERINAMIDE, GLYCINAMIDE, ALANINAMIDE AND PHENYLALANINAMIDE FOR TREATING NEUROLOGICAL DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2000-09-05 | — | — | US | disclosed |