Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133880 | 0.89 | LRRK2 (0.48) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7133184 | 0.87 | KDM1A (0.52) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7136631 | 0.85 | LRRK2 (0.43) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7139429 | 0.85 | ERBB2 (0.53) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7139026 | 0.85 | MEN1 (0.40) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7132141 | 0.83 | KMT2A (0.53) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7132027 | 0.83 | ERBB2 (0.60) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7137078 | 0.82 | KDM1A (0.52) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL7130885 | 0.82 | SIRT1 (0.41) | MEN1KMT2AMAPTTDP1PLK4 | |
| SCHEMBL5358747 | 0.82 | PLK4 (0.60) | MEN1KMT2AMAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |