Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | ARAF | P10398 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133862 | 0.88 | EEF2K (0.47) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL7133993 | 0.88 | METAP1 (0.50) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL7134037 | 0.88 | MAP1LC3B (0.45) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL7131324 | 0.86 | MAP1LC3B (0.52) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL7136631 | 0.84 | LRRK2 (0.43) | LRRK2EGFRMEN1PLK4USP2 | |
| SCHEMBL7133805 | 0.84 | SIRT1 (0.36) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL7132917 | 0.84 | EGFR (0.51) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL7138236 | 0.84 | EGFR (0.51) | EGFRMEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL7133880 | 0.83 | LRRK2 (0.48) | SIRT1SIRT2SIRT3LRRK2RAF1 | |
| SCHEMBL8193593 | 0.83 | PLK4 (0.51) | LRRK2MEN1PLK4MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| US-6133305-A | PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISORDERS SUCH AS CANCER | SUGEN, INC. (US) | 2000-10-17 | — | — | US | disclosed |