Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.81 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | PGR | P06401 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.81 |
| ▸ | SHBG | P04278 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL7142721 | 1.00 | HIF1A (0.81) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL7144941 | 1.00 | HIF1A (0.81) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL4886137 | 1.00 | HIF1A (0.81) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL5084685 | 0.99 | HIF1A (0.82) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL80605 | 0.98 | HIF1A (0.85) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL28435897 | 0.96 | HIF1A (0.82) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL29263567 | 0.96 | HIF1A (0.82) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL29180382 | 0.95 | HIF1A (0.73) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL7031047 | 0.94 | HIF1A (0.71) | HIF1ANR3C2NR3C1SMN1; SMN2PGR | |
| Hydrocortisone SCHEMBL28908729 | 0.93 | HIF1A (0.86) | HIF1ANR3C2NR3C1SMN1; SMN2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041772-B2 | FAT EMULSION CONTAINING A STEROID | GREEN CROSS CORPORATION (JP) | 1990-04-18 | — | — | EP | claimed |
| EP-0041772-B1 | FAT EMULSION CONTAINING A STEROID | GREEN CROSS CORPORATION (JP) | 1984-10-17 | — | — | EP | claimed |
| US-4340594-A | Fat emulsion containing steroid | THE GREEN CROSS CORPORATION (JP) | 1982-07-20 | — | — | US | claimed |
| EP-0041772-A2 | Fat emulsion containing a steroid | GREEN CROSS CORPORATION (JP) | 1981-12-16 | — | — | EP | claimed |
| EP-0331755-B2 | MEDICINE-CONTAINING FAT EMULSION OF THE TYPE PREPARED IMMEDIATELY BEFORE USE AND PROCESS FOR PREPARING MEDICINE-CONTAINING FAT EMULSION | TEIJIN LTD (JP) | 2003-02-05 | — | — | EP | disclosed |
| EP-0331755-B1 | MEDICINE-CONTAINING FAT EMULSION OF THE TYPE PREPARED IMMEDIATELY BEFORE USE AND PROCESS FOR PREPARING MEDICINE-CONTAINING FAT EMULSION | TEIJIN LIMITED (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-5229422-A | Drug delivery | TEIJIN LIMITED (JP) | 1993-07-20 | — | — | US | disclosed |
| EP-0041772-B2 | FAT EMULSION CONTAINING A STEROID | GREEN CROSS CORPORATION (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0331755-A1 | MEDICINE-CONTAINING FAT EMULSION OF THE TYPE PREPARED IMMEDIATELY BEFORE USE AND PROCESS FOR PREPARING MEDICINE-CONTAINING FAT EMULSION | TEIJIN LIMITED (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0041772-B1 | FAT EMULSION CONTAINING A STEROID | GREEN CROSS CORPORATION (JP) | 1984-10-17 | — | — | EP | disclosed |
| US-4340594-A | Fat emulsion containing steroid | THE GREEN CROSS CORPORATION (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0041772-A2 | Fat emulsion containing a steroid | GREEN CROSS CORPORATION (JP) | 1981-12-16 | — | — | EP | disclosed |