Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.82 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.82 |
| ▸ | PGR | P06401 | 3/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.82 |
| ▸ | SHBG | P04278 | 2/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | AR | P10275 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL7142721 | 0.99 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7137205 | 0.99 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL4886137 | 0.99 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7144941 | 0.99 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL80605 | 0.98 | HIF1A (0.85) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL28435897 | 0.97 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL29263567 | 0.97 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL29180382 | 0.95 | HIF1A (0.73) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL28908729 | 0.94 | HIF1A (0.86) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL4697 | 0.94 | HIF1A (0.86) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080166398-A1 | Sertaconazole and hydrocortisone; for dermal diseases; inflammation | FERRER INTERNACIONAL, S.A. (ES) | 2008-07-10 | — | — | US | claimed |
| EP-1858510-A1 | ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND | FERRER INTERNACIONAL, S.A. (ES) | 2007-11-28 | — | — | EP | claimed |
| WO-2006092374-A1 | ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND | FERRER INTERNACIONAL, S. A. (ES) | 2006-09-08 | — | — | WO | claimed |
| EP-1698336-A1 | Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent | FERRER INTERNACIONAL, S.A. (ES) | 2006-09-06 | — | — | EP | claimed |
| US-20080166398-A1 | Sertaconazole and hydrocortisone; for dermal diseases; inflammation | FERRER INTERNACIONAL, S.A. (ES) | 2008-07-10 | — | — | US | disclosed |
| EP-1858510-A1 | ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND | FERRER INTERNACIONAL, S.A. (ES) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006092374-A1 | ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND | FERRER INTERNACIONAL, S. A. (ES) | 2006-09-08 | — | — | WO | disclosed |
| EP-1698336-A1 | Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent | FERRER INTERNACIONAL, S.A. (ES) | 2006-09-06 | — | — | EP | disclosed |
| EP-1308500-A1 | Ophthalmic composition | Menicon Co., Ltd. (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-5489576-A | ADMINISTERING ASCORBIC ACID ALPHA-TOCOPHERYL PHOSPHATE DIESTER | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1996-02-06 | — | — | US | disclosed |
| EP-0661053-A1 | Use of tocopherol ascorbic adic phosphates for hemorrhoidal diseases | Senju Pharmaceutical Co., Ltd. (JP) | 1995-07-05 | — | — | EP | disclosed |