Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366299 | 0.89 | LRRK2 (0.53) | MAP3K7TAB1PLK4PLK1MEN1 | |
| SCHEMBL5359526 | 0.86 | NPC1 (0.51) | PLK4PLK1MEN1KMT2ALRRK2 | |
| SCHEMBL5374178 | 0.84 | MAP3K7 (0.48) | MAP3K7TAB1PLK4PLK1MEN1 | |
| SCHEMBL5363550 | 0.84 | IGF1R (0.49) | MAP3K7TAB1PLK4PLK1MEN1 | |
| SCHEMBL7139603 | 0.82 | MEN1 (0.49) | PLK4PLK1MEN1KMT2APDPK1 | |
| SCHEMBL7136229 | 0.82 | MAP1LC3B (0.57) | PLK4PLK1MEN1KMT2ARAF1 | |
| SCHEMBL5367186 | 0.82 | LRRK2 (0.53) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7137072 | 0.82 | NPC1 (0.50) | PLK4PLK1MEN1KMT2APDPK1 | |
| SCHEMBL7139419 | 0.81 | MEN1 (0.67) | PLK4PLK1MEN1KMT2APDPK1 | |
| SCHEMBL7136594 | 0.81 | NPC1 (0.62) | PLK4PLK1MEN1KMT2APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |