Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | MMP13 | P45452 | 13/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143126 | 0.91 | MMP1 (0.48) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7137901 | 0.86 | MMP1 (0.47) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7142256 | 0.84 | MMP2 (0.41) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7137896 | 0.82 | MMP1 (0.57) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL8474485 | 0.82 | MMP1 (0.70) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7136790 | 0.81 | MMP1 (0.59) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7134718 | 0.80 | MMP1 (0.58) | MMP1MMP13ADAM17 | |
| SCHEMBL7136825 | 0.78 | MMP1 (0.47) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7139183 | 0.78 | MMP1 (0.59) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7141116 | 0.77 | MMP1 (0.51) | MMP1MMP13ADAM17MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041072-B1 | Dioxocyclopentyl hydroxamic acids | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6214870-B1 | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS | PFIZER INC | 2001-04-10 | — | — | US | disclosed |
| EP-1041072-A1 | Dioxocyclopentyl hydroxamic acids | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |