Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138182 | 0.87 | KMT2A (0.42) | ALDH1A1RETMAPTSIRT1SIRT2 | |
| SCHEMBL7138862 | 0.87 | MAPT (0.47) | ALDH1A1POLBRETMAPTSIRT1 | |
| SCHEMBL7135160 | 0.85 | METAP1 (0.50) | ALDH1A1POLBRETMAPTSIRT2 | |
| SCHEMBL7136076 | 0.85 | LRRK2 (0.42) | GSK3BSIRT1SIRT2SIRT3PSEN1 | |
| SCHEMBL7133993 | 0.85 | METAP1 (0.50) | GSK3BALDH1A1POLBRETMAPT | |
| SCHEMBL7136101 | 0.84 | RET (0.44) | POLBRETGAASIRT1SIRT2 | |
| SCHEMBL7131272 | 0.82 | SIRT2 (0.52) | ALDH1A1POLBRETMAPTSIRT1 | |
| SCHEMBL7138840 | 0.82 | RET (0.55) | ALDH1A1RETMAPTGAASIRT1 | |
| SCHEMBL7138260 | 0.82 | METAP1 (0.55) | GSK3BPOLBRETMETAP1 | |
| SCHEMBL7138851 | 0.82 | IGF1R (0.44) | ALDH1A1RETMAPTGAASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |