Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138182 | 0.89 | KMT2A (0.42) | RETPLK4MAPTALDH1A1MEN1 | |
| SCHEMBL7138862 | 0.89 | MAPT (0.47) | METAP1RETMAPTALDH1A1MEN1 | |
| SCHEMBL7130885 | 0.88 | SIRT1 (0.41) | METAP1RETPLK4PLK1PSEN1 | |
| SCHEMBL7138262 | 0.87 | LRRK2 (0.51) | PLK4LRRK2MAPTALDH1A1MEN1 | |
| SCHEMBL8193593 | 0.87 | PLK4 (0.51) | PLK4LRRK2MAPTALDH1A1MEN1 | |
| SCHEMBL7135160 | 0.87 | METAP1 (0.50) | METAP1RETPDGFRBMAPTALDH1A1 | |
| SCHEMBL7136076 | 0.87 | LRRK2 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7136101 | 0.86 | RET (0.44) | RETLRRK2MEN1KMT2AHPGD | |
| SCHEMBL7132053 | 0.86 | METAP1 (0.53) | METAP1RETMAPTALDH1A1MEN1 | |
| SCHEMBL7139926 | 0.86 | LRRK2 (0.42) | PLK4LRRK2MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |