Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138862 | 0.92 | MAPT (0.47) | KMT2AMAPTALDH1A1PIM1PIM2 | |
| SCHEMBL7136076 | 0.89 | LRRK2 (0.42) | PIM1PIM2SIRT2SIRT1SIRT3 | |
| SCHEMBL7133993 | 0.89 | METAP1 (0.50) | KMT2AMAPTALDH1A1MEN1SIRT2 | |
| SCHEMBL7135160 | 0.89 | METAP1 (0.50) | KMT2AMAPTALDH1A1PIM1PIM2 | |
| SCHEMBL7136101 | 0.89 | RET (0.44) | KMT2AMEN1SIRT2SIRT1SIRT3 | |
| SCHEMBL7137997 | 0.87 | GSK3B (0.44) | MAPTALDH1A1SIRT2SIRT1SIRT3 | |
| SCHEMBL7138851 | 0.87 | IGF1R (0.44) | KMT2AMAPTALDH1A1PIM1PIM2 | |
| SCHEMBL7138260 | 0.87 | METAP1 (0.55) | KMT2APIM1PIM2MEN1KDM1A | |
| SCHEMBL7131272 | 0.87 | SIRT2 (0.52) | MAPTALDH1A1PIM1SIRT2SIRT1 | |
| SCHEMBL7138840 | 0.87 | RET (0.55) | KMT2AMAPTALDH1A1MEN1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |