Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 4/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139979 | 0.88 | ALDH1A1 (0.40) | EGLN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5869099 | 0.86 | EGLN2 (0.38) | EGLN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7142179 | 0.83 | DHODH (0.34) | DHODHALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7141522 | 0.82 | ALDH1A1 (0.42) | EGLN2GPR6ALDH1A1KMT2AMEN1 | |
| SCHEMBL7145960 | 0.82 | EGLN2 (0.36) | EGLN2DHODHALDH1A1KMT2AMEN1 | |
| SCHEMBL7140010 | 0.81 | MEN1 (0.36) | EGLN2DHODHALDH1A1KMT2AMEN1 | |
| SCHEMBL7142038 | 0.81 | HTT (0.36) | EGLN2DHODHALDH1A1KMT2AMEN1 | |
| SCHEMBL7704394 | 0.78 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL7143926 | 0.76 | DHODH (0.34) | EGLN2DHODH | |
| SCHEMBL7140101 | 0.75 | KCNQ4 (0.36) | EGLN2ALDH1A1KMT2AMEN1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |