Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.45 |
| ▸ | ESRRG | P62508 | 6/20 | 0.45 |
| ▸ | ESRRB | O95718 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137789 | 0.86 | CHEK1 (0.42) | ESR1ESRRGESRRBKCNH2CHRM3 | |
| SCHEMBL7146903 | 0.86 | ESR1 (0.57) | ESR1KCNH2ESR2CHRM3MLNR | |
| SCHEMBL7139552 | 0.85 | ESR1 (0.58) | ESR1KCNH2ESR2CHRM3MLNR | |
| SCHEMBL7142360 | 0.83 | CHRNB4 (0.43) | ESR1ESR2CHRM3HRH3CHRNB4 | |
| SCHEMBL7144464 | 0.81 | CHRM3 (0.39) | ESR1ESRRGESRRBKCNH2CHRM3 | |
| SCHEMBL7140944 | 0.78 | ESR1 (0.56) | ESR1KCNH2ESR2CHRM3MLNR | |
| SCHEMBL7525151 | 0.78 | ESR1 (0.58) | ESR1ESRRGESRRBKCNH2ESR2 | |
| SCHEMBL7139824 | 0.78 | ESR1 (0.56) | ESR1KCNH2ESR2CHRM3MLNR | |
| SCHEMBL7136715 | 0.77 | ESR1 (0.55) | ESR1KCNH2ESR2CHRM3MLNR | |
| SCHEMBL7146404 | 0.77 | ESR1 (0.55) | ESR1KCNH2ESR2CHRM3MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832880-B1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0832880-A1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |