Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145058 | 0.89 | EBP (0.40) | CHRNB4CHRNA3EBPSIGMAR1ESR1 | |
| SCHEMBL7163311 | 0.86 | EBP (0.58) | EBPSIGMAR1ESR1ESR2HTR1A | |
| SCHEMBL7141345 | 0.85 | EBP (0.57) | EBPSIGMAR1ESR1ESR2HTR1A | |
| SCHEMBL7137789 | 0.83 | CHEK1 (0.42) | CHRNB4CHRNA3ESR1CHRM3CHEK1 | |
| SCHEMBL7138229 | 0.83 | ESR1 (0.45) | CHRNB4CHRNA3ESR1ESR2CHRM3 | |
| SCHEMBL7144464 | 0.81 | CHRM3 (0.39) | CHRNB4CHRNA3EBPSIGMAR1ESR1 | |
| SCHEMBL7139748 | 0.80 | ESR1 (0.55) | EBPSIGMAR1ESR1ESR2CHRM3 | |
| SCHEMBL7146404 | 0.80 | ESR1 (0.55) | EBPSIGMAR1ESR1ESR2CHRM3 | |
| SCHEMBL7141350 | 0.80 | ESR1 (0.57) | EBPSIGMAR1ESR1ESR2CHRM3 | |
| SCHEMBL7143964 | 0.80 | ESR1 (0.57) | EBPSIGMAR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832880-B1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0832880-A1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |