Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 6/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145058 | 0.93 | EBP (0.40) | CHRM3CHRNB4CHRNA3CHEK1ESR1 | |
| SCHEMBL7137789 | 0.87 | CHEK1 (0.42) | CHRM3CHRNB4CHRNA3CHEK1SLC2A1 | |
| SCHEMBL7145649 | 0.86 | EBP (0.49) | ESR1EBPSIGMAR1KCNH2 | |
| SCHEMBL7144936 | 0.86 | EBP (0.49) | ESR1EBPSIGMAR1KCNH2 | |
| SCHEMBL7142360 | 0.81 | CHRNB4 (0.43) | CHRM3CHRNB4CHRNA3CHEK1ESR1 | |
| SCHEMBL7138229 | 0.81 | ESR1 (0.45) | CHRM3CHRNB4CHRNA3ESRRGESR1 | |
| SCHEMBL7528581 | 0.78 | ESR1 (0.41) | CHRM3CHRNB4CHRNA3ESRRGESR1 | |
| SCHEMBL7139953 | 0.78 | EBP (0.54) | ESR1EBPSIGMAR1 | |
| SCHEMBL7529608 | 0.76 | ESR1 (0.43) | CHRM3CHRNB4CHRNA3CHEK1ESRRG | |
| SCHEMBL7136715 | 0.75 | ESR1 (0.55) | CHRM3ESR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832880-B1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0832880-A1 | Dihydrobenzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |