Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | LTK | P29376 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CDK7 | P50613 | 2/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.52 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132142 | 0.84 | NTRK1 (0.58) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL7138169 | 0.82 | POLB (0.42) | RETKDRFLT3MAPTALDH1A1 | |
| SCHEMBL7139425 | 0.81 | KMT2A (0.49) | RETKDRFLT3MAPTKDM4E | |
| SCHEMBL7139112 | 0.80 | PIK3CA (0.41) | KDRCDK7AURKBCDK5MAPT | |
| SCHEMBL7134889 | 0.79 | DYRK1A (0.39) | KDRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7134752 | 0.79 | PLK4 (0.48) | PDGFRBCSF1RMAPTALDH1A1MEN1 | |
| SCHEMBL7138946 | 0.79 | NPC1 (0.48) | KDRFLT3MAP2K1MAPTKDM4E | |
| SCHEMBL7136101 | 0.78 | RET (0.44) | RETLRRK2HPGDNPC1RAB9A | |
| SCHEMBL7139579 | 0.78 | RET (0.38) | NTRK1RETPRKD3KDRFLT3 | |
| SCHEMBL7133179 | 0.78 | KMT2A (0.60) | NTRK1RETPRKD3KDRCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |