Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193593 | 0.93 | PLK4 (0.51) | LRRK2CISD1MEN1KMT2APLK4 | |
| SCHEMBL7139926 | 0.91 | LRRK2 (0.42) | LRRK2CISD1MEN1KMT2ASIRT1 | |
| SCHEMBL7135662 | 0.87 | ERBB2 (0.41) | LRRK2CISD1MEN1KMT2ASIRT1 | |
| SCHEMBL7133993 | 0.87 | METAP1 (0.50) | LRRK2MEN1KMT2ASIRT1PLK4 | |
| SCHEMBL7136068 | 0.85 | GSK3B (0.50) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7131324 | 0.85 | MAP1LC3B (0.52) | LRRK2CISD1MEN1KMT2ASIRT1 | |
| SCHEMBL7137722 | 0.85 | KDM1A (0.54) | MEN1KMT2APLK4ALDH1A1MAPT | |
| SCHEMBL7134037 | 0.85 | MAP1LC3B (0.45) | LRRK2CISD1MEN1KMT2ASIRT1 | |
| SCHEMBL7133939 | 0.84 | PIM1 (0.53) | MEN1KMT2ASIRT1ALDH1A1MAPT | |
| SCHEMBL7138862 | 0.84 | MAPT (0.47) | MEN1KMT2ASIRT1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |