Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133184 | 0.91 | KDM1A (0.52) | MAPTKMT2AALDH1A1PDE4BPDE3A | |
| SCHEMBL7133939 | 0.88 | PIM1 (0.53) | MAPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL7132141 | 0.86 | KMT2A (0.53) | MAPTKMT2AALDH1A1PDE4BMEN1 | |
| SCHEMBL5357895 | 0.85 | IGF1R (0.53) | IGF1RMAPTKMT2AALDH1A1PDE4B | |
| SCHEMBL7136184 | 0.84 | ERBB2 (0.43) | MAPTKMT2AALDH1A1PDE4BMEN1 | |
| SCHEMBL7137722 | 0.84 | KDM1A (0.54) | MAPTKMT2AALDH1A1MEN1DYRK1A | |
| SCHEMBL7139008 | 0.84 | PIM1 (0.47) | MAPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL7135307 | 0.83 | ERBB2 (0.57) | MAPTKMT2AALDH1A1PDE4BMEN1 | |
| SCHEMBL7137199 | 0.81 | MEN1 (0.58) | IGF1RMAPTKMT2AALDH1A1PDE4B | |
| SCHEMBL7138260 | 0.80 | METAP1 (0.55) | KMT2AMEN1L3MBTL1DYRK1AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |