Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981343 | 0.87 | MAPT (0.67) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL18629105 | 0.82 | MAPT (0.60) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL21476709 | 0.81 | MAPT (0.58) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL5010663 | 0.80 | MAPT (0.68) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL1720494 | 0.80 | MAPT (0.72) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL20827464 | 0.79 | MAPT (0.76) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL5885563 | 0.78 | MAPT (0.70) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL900124 | 0.78 | MAPT (0.70) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL20827047 | 0.78 | MAPT (0.63) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL1981006 | 0.78 | MAPT (0.64) | MAPTKDM4EALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |