Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 16/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139924 | 0.79 | MEN1 (0.74) | MEN1KMT2AFFAR2HTR6 | |
| SCHEMBL6416429 | 0.75 | HTR6 (0.43) | MEN1KMT2AHTR6 | |
| SCHEMBL9593839 | 0.71 | CA12 (0.47) | MEN1KMT2AFFAR2 | |
| SCHEMBL7144381 | 0.71 | HTR6 (0.48) | MEN1KMT2AFFAR2HTR6 | |
| SCHEMBL6416457 | 0.69 | AKR1B1 (0.43) | MEN1KMT2AHTR6AKR1B1 | |
| SCHEMBL25009043 | 0.68 | FFAR2 (0.41) | MEN1KMT2AFFAR2HTR6AKR1B1 | |
| SCHEMBL27470230 | 0.67 | HTR6 (0.63) | MEN1KMT2AFFAR2HTR6 | |
| SCHEMBL7140839 | 0.66 | KMT2A (0.77) | MEN1KMT2AFFAR2HTR6AKR1B1 | |
| SCHEMBL23415979 | 0.65 | MAPT (0.38) | MEN1KMT2AFFAR2HTR6AKR1B1 | |
| SCHEMBL19116025 | 0.64 | GSK3B (0.43) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1118468-C | Pyrazolopyrimidines and pyrazolotriazines | HOFFMANN LA ROCHE (CH) | 2003-08-20 | — | — | CN | disclosed |
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| CN-1236780-A | Pyrazolopyrimidines and pyrazolotriazines | HOFFMANN LA ROCHE (CH) | 1999-12-01 | — | — | CN | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |