Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6043362 | 0.85 | SIGMAR1 (0.49) | BRD4HRH3MEN1KMT2APOLB | |
| SCHEMBL3454127 | 0.84 | HDAC3 (0.56) | BRD4ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL27669691 | 0.84 | HRH3 (0.56) | HRH3ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15058449 | 0.83 | HDAC3 (0.55) | BRD4ALDH1A1KDM4ELMNAHTT | |
| Hydrochloric Acid SCHEMBL30279971 | 0.83 | HDAC3 (0.55) | BRD4ALDH1A1KDM4ELMNAHTT | |
| Hydrochloric Acid SCHEMBL17338492 | 0.83 | HDAC3 (0.55) | BRD4ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL7484815 | 0.83 | SIGMAR1 (0.60) | ALDH1A1KDM4ELMNATSHRMEN1 | |
| SCHEMBL7433040 | 0.82 | ALDH1A1 (0.67) | BRD4ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL21043973 | 0.81 | ALDH1A1 (0.55) | BRD4ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL30576825 | 0.81 | CHRM2 (0.52) | ALDH1A1KDM4ELMNAHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301497-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | Angiogene Pharmaceuticals Limited (GB) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004434-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2002-01-17 | — | — | WO | disclosed |