Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15999467 | 1.00 | HTR2C (0.42) | HTR2CHTR2AHTR2BHRH1HTR6 | |
| SCHEMBL254983 | 0.89 | HTR2C (0.42) | HTR2CHTR2AHRH1HTR6SRD5A1 | |
| SCHEMBL12951637 | 0.87 | HTR2C (0.38) | HTR2CHTR2AHTR2BHRH1HTR6 | |
| SCHEMBL11840313 | 0.80 | HTR2C (0.40) | HTR2CHTR2AHTR2BHTR6SRD5A1 | |
| SCHEMBL11568676 | 0.78 | SLC18A3 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL11052131 | 0.78 | SLC18A3 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL11052133 | 0.78 | SLC18A3 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL11400396 | 0.78 | CDC25A (0.39) | HTR2CHTR2AHTR2BHRH1 | |
| SCHEMBL11403821 | 0.78 | CDC25A (0.39) | HTR2CHTR2AHTR2BHRH1 | |
| SCHEMBL21913053 | 0.78 | HRH1 (0.48) | HRH1HTR6SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902684-B1 | HEXAHYDRO-PYRIDO(4,3-B)INDOLE DERIVATIVES AS ANTIPSYCHOTIC DRUGS | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6057325-A | HAVE CENTRAL DOPAMINE AND SEROTONIN ANTOGONISTIC ACTIVITY | JANSSEN PHARMACEUTIA, N.V. (BE) | 2000-05-02 | — | — | US | disclosed |