Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29864521 | 0.84 | CYP1A2 (0.64) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL7140600 | 0.83 | SCN2A (0.52) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL7143456 | 0.82 | SCN2A (0.51) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL8189931 | 0.79 | SCN2A (0.50) | CYP1A2CYP2D6CYP2C19CNR1CNR2 | |
| SCHEMBL21648321 | 0.78 | CYP1A2 (0.59) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL9257479 | 0.77 | CYP1A2 (0.76) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL15859362 | 0.77 | CYP1A2 (0.76) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL538475 | 0.77 | MAOA (0.76) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL29692481 | 0.77 | CYP1A2 (0.62) | CYP1A2CYP2D6CYP2C19HRH4HRH3 | |
| SCHEMBL16436983 | 0.76 | CYP1A2 (0.61) | CYP1A2CYP2D6CYP2C19HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |