Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140758 | 0.88 | HTR6 (0.62) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7143714 | 0.88 | HTR6 (0.62) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7138600 | 0.88 | HTR6 (0.65) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7138402 | 0.87 | HTR6 (0.59) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7143666 | 0.84 | HTR6 (0.60) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7136657 | 0.82 | HTR6 (0.61) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7143107 | 0.81 | HTR6 (0.59) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7140803 | 0.81 | HTR6 (0.59) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7137463 | 0.80 | HTR6 (0.56) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7142236 | 0.78 | HTR6 (0.56) | HTR6HTR2AHTR1DHTR2CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |