Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143107 | 0.90 | HTR6 (0.59) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7138600 | 0.84 | HTR6 (0.65) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7140803 | 0.84 | HTR6 (0.59) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7143113 | 0.81 | HTR6 (0.56) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7137463 | 0.81 | HTR6 (0.56) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7143666 | 0.81 | HTR6 (0.60) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7143714 | 0.80 | HTR6 (0.62) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7140658 | 0.78 | HTR6 (0.62) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7140758 | 0.78 | HTR6 (0.62) | HTR6HTR2APIK3CAAKT1MTOR | |
| SCHEMBL7136657 | 0.77 | HTR6 (0.61) | HTR6HTR2APIK3CAAKT1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |