Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.57 |
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.57 |
| ▸ | FLT1 | P17948 | 9/20 | 0.57 |
| ▸ | FLT4 | P35916 | 8/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252484 | 0.84 | KDR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7150412 | 0.82 | KDR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7148463 | 0.81 | KDR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3678100 | 0.80 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3668100 | 0.80 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3670246 | 0.80 | KDR (0.70) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7147819 | 0.80 | KDR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3673833 | 0.79 | SRC (0.81) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7146877 | 0.79 | SRC (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7848480 | 0.77 | RET (0.70) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326859-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | claimed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | claimed |
| WO-2002030924-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | claimed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | disclosed |