Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17906205 | 0.84 | KDM4E (0.59) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29415 | 0.84 | MAPT (0.62) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29539968 | 0.84 | MAPT (0.62) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18969703 | 0.82 | KDM4E (0.47) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11379057 | 0.82 | KDM4E (0.61) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2758580 | 0.79 | KDM4E (0.44) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17906201 | 0.79 | KDM4E (0.44) | MAPTALDH1A1HPGDKDM4EHTT | |
| SCHEMBL2512529 | 0.79 | MAPT (0.57) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18031551 | 0.79 | MAPT (0.53) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12334438 | 0.78 | HTT (0.70) | MAPTLMNAHPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | claimed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | claimed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | claimed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | claimed |
| US-20030069337-A1 | Stabilizer mixtures for polyolefins | CIBA SPECIALTY CHEMICALS CORP. | 2003-04-10 | — | — | US | disclosed |
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | disclosed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | disclosed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065266-A1 | Use of ion channel modulating agents | KCNN3, KCNN1, KCNN2 | MAPT 2398/4885LMNA 1889/4885ALDH1A1 4532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.