Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.58 |
| ▸ | THRB | P10828 | 14/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989238 | 0.88 | THRA (0.57) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7093101 | 0.83 | THRA (0.62) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088864 | 0.83 | THRA (0.47) | THRATHRBAR | |
| SCHEMBL7088995 | 0.83 | THRA (0.56) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7090270 | 0.80 | THRA (0.56) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7082352 | 0.80 | THRA (0.69) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7093058 | 0.79 | THRA (0.41) | THRATHRBHTR2B | |
| SCHEMBL6987444 | 0.79 | THRA (0.49) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7171265 | 0.79 | THRA (0.49) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7090894 | 0.78 | THRA (0.41) | THRATHRBMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |