Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.69 |
| ▸ | THRB | P10828 | 13/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089038 | 0.89 | THRA (0.58) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6524689 | 0.85 | THRB (0.77) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6519479 | 0.85 | THRA (0.74) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6516990 | 0.85 | THRA (0.74) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7086992 | 0.84 | THRA (0.49) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7091904 | 0.83 | THRA (0.66) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6513386 | 0.83 | THRA (0.71) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088760 | 0.83 | THRA (0.52) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7093101 | 0.83 | THRA (0.62) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7086230 | 0.83 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |