Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 7/20 | 0.46 |
| ▸ | MME | P08473 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CCR4 | P51679 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7151406 | 0.97 | ECE1 (0.44) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7140077 | 0.87 | ECE1 (0.49) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7137883 | 0.84 | ECE1 (0.47) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7151410 | 0.80 | ECE1 (0.43) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7143261 | 0.79 | ECE1 (0.64) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7135712 | 0.79 | ECE1 (0.53) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7143376 | 0.77 | ECE1 (0.62) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7148868 | 0.76 | MME (0.47) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7136108 | 0.76 | ALDH1A1 (0.50) | ECE1MMEACEALDH1A1CCR4 | |
| SCHEMBL7141766 | 0.73 | ECE1 (0.60) | ECE1MMEACEALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |