SCHEMBL7141401

SCHEMBL7141401

CC(C)n1c(CO)c(-c2ccc(F)cc2)c2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 6/20 0.50
CYP2C9 P11712 4/20 0.50
SIRT6 Q8N6T7 2/20 0.50
ABCC3 O15438 1/20 0.50
ABCB11 O95342 1/20 0.50
PGR P06401 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
RXRA P19793 1/20 0.50
TBXA2R P21731 1/20 0.50
CCKAR P32238 1/20 0.50
ADRA1A P35348 1/20 0.50
PTGS2 P35354 1/20 0.50
NR4A2 P43354 1/20 0.50
PDE4D Q08499 1/20 0.50
SLC10A1 Q14973 1/20 0.50
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
CYP1A2 P05177 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14026609 0.87 HMGCR (0.48) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL7142742 0.86 HMGCR (0.47) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL3993339 0.86 HMGCR (0.47) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL9764062 0.84 CDC25A (0.44) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL10563970 0.83 HMGCR (0.48) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL18947946 0.82 HMGCR (0.44) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL18947945 0.82 HMGCR (0.44) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL9301103 0.81 MAPK14 (0.56) KDM4EALDH1A1LMNASMN1; SMN2MAPK14
SCHEMBL3390057 0.81 CYP2C9 (0.49) HMGCRCYP2C9SIRT6ABCC3ABCB11
SCHEMBL13428829 0.81 HMGCR (0.46) HMGCRCYP2C9SIRT6ABCC3ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003083063-A2 COMMON LIGAND MIMICS: NAPHTOATES TRIAD THERAPEUTICS, INC. (US) 2003-10-09 WO disclosed
US-5276021-A Anticholesterol or antilipemic agents E. R. SQUIBB & SONS, INC. (US) 1994-01-04 US disclosed
US-5091378-A Anticholesterol agents E. R. SQUIBB & SONS, INC. (US) 1992-02-25 US disclosed
US-4870199-A FROM 3-HYDROXY-4-TRIPHENYLMETHOXYBUTANOIC ACID SANDOZ PHARM. CORP. (US) 1989-09-26 US disclosed
EP-0244364-A2 Preparation of olefinic compounds SANDOZ AG (CH) 1987-11-04 EP disclosed