Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | F2R | P25116 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | CENPE | Q02224 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299635 | 0.85 | MAPK14 (0.56) | MAPK14KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL7141401 | 0.81 | HMGCR (0.50) | MAPK14LMNASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL10551162 | 0.78 | MAPK14 (0.52) | MAPK14KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL9302124 | 0.73 | L3MBTL1 (0.59) | MAPK14KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17883127 | 0.72 | L3MBTL1 (0.53) | MAPK14KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL9301200 | 0.72 | ELANE (0.53) | MAPK14KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14026609 | 0.71 | HMGCR (0.48) | MAPK14LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9764062 | 0.71 | CDC25A (0.44) | MAPK14LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7142742 | 0.70 | HMGCR (0.47) | MAPK14MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3993339 | 0.70 | HMGCR (0.47) | MAPK14LMNASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354772-A | Anticholesterol agents | SANDOZ PHARM. CORP. (US) | 1994-10-11 | — | — | US | disclosed |
| US-4739073-A | ANTICHOLESTEROL AGENTS | SANDOZ PHARMACEUTICALS CORP. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0114027-B1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1988-01-07 | — | — | EP | disclosed |
| EP-0114027-A1 | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| WO-1984002131-A1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1984-06-07 | — | — | WO | disclosed |